Brasil

Brasil:


  1. CYP2D6

Silveira Vda S, Canalle R, Scrideli CA, Queiroz RG, Tone LG. Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes in a Brazilian population. Biomarkers. 2009 Mar;14(2):111-7.

Maciel ME, Oliveira FK, Propst GB, da Graça Bicalho M, Cavalli IJ, Ribeiro EM. Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants. Genet Mol Biol. 2009 Oct;32(4):723-8.

Kohlrausch FB, Gama CS, Lobato MI, Belmonte-de-Abreu P, Gesteira A, Barros F, Carracedo A, Hutz MH. Molecular diversity at the CYP2D6 locus in healthy and schizophrenic southern Brazilians. Pharmacogenomics. 2009 Sep;10(9):1457-66. ABSTRACT; NO PDF

  1. CYP2C9

Perini JA, Vargens DD, Santana IS, Moriguchi EH, Ribeiro-Dos-Santos AK, Tsutsumi M, Suarez-Kurtz G. Pharmacogenetic polymorphisms in Brazilian-born, first-generation Japanese descendants. Braz J Med Biol Res. 2009 Dec;42(12):1179-84.

Suarez-Kurtz G, Genro JP, de Moraes MO, Ojopi EB, Pena SD, Perini JA, Ribeiro-dos-Santos A, Romano-Silva MA, Santana I, Struchiner CJ. Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians. Pharmacogenomics J. 2012 Jun;12(3):267-76.

Vargens DD, Petzl-Erler ML, Suarez-Kurtz G. Distribution of CYP2C polymorphisms in an Amerindian population of Brazil. Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):396-400.

Vianna-Jorge R, Perini JA, Rondinelli E, Suarez-Kurtz G. CYP2C9 genotypes and the pharmacokinetics of tenoxicam in Brazilians. Clin Pharmacol Ther. 2004 Jul;76(1):18-26.ABSTRACT; NO PDF

  1. CYP2C19

Perini JA, Vargens DD, Santana IS, Moriguchi EH, Ribeiro-Dos-Santos AK, Tsutsumi M, Suarez-Kurtz G. Pharmacogenetic polymorphisms in Brazilian-born, first-generation Japanese descendants. Braz J Med Biol Res. 2009 Dec;42(12):1179-84.

Rocha A, Coelho EB, Moussa SA, Lanchote VL. Investigation of the in vivo activity of CYP3A in Brazilian volunteers: comparison of midazolam and omeprazole as drug markers. Eur J Clin Pharmacol. 2008 Sep;64(9):901-6.

Santos PC, Soares RA, Santos DB, Nascimento RM, Coelho GL, Nicolau JC, Mill JG, Krieger JE, Pereira AC. CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population. BMC Med Genet. 2011 Jan 19;12:13.

Suarez-Kurtz G, Genro JP, de Moraes MO, Ojopi EB, Pena SD, Perini JA, Ribeiro-dos-Santos A, Romano-Silva MA, Santana I, Struchiner CJ. Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians. Pharmacogenomics J. 2012 Jun;12(3):267-76.

Vargens DD, Petzl-Erler ML, Suarez-Kurtz G. Distribution of CYP2C polymorphisms in an Amerindian population of Brazil. Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):396-400.

  1. ABCB1

Santos PC, Soares RA, Santos DB, Nascimento RM, Coelho GL, Nicolau JC, Mill JG, Krieger JE, Pereira AC. CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population. BMC Med Genet. 2011 Jan 19;12:13.

  1. CYP2C8

Suarez-Kurtz G, Genro JP, de Moraes MO, Ojopi EB, Pena SD, Perini JA, Ribeiro-dos-Santos A, Romano-Silva MA, Santana I, Struchiner CJ. Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians. Pharmacogenomics J. 2012 Jun;12(3):267-76.

Vargens DD, Petzl-Erler ML, Suarez-Kurtz G. Distribution of CYP2C polymorphisms in an Amerindian population of Brazil. Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):396-400.

  1. CYP2A6

Rossini A, Lima SS, Rapozo DC, Faria M, Albano RM, Pinto LF. CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro. Braz J Med Biol Res. 2006 Feb;39(2):195-201.

Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, Matos HJ, Albano RM, Pinto LF. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis. 2007 Dec;28(12):2537-42.

Vasconcelos GM, Struchiner CJ, Suarez-Kurtz G. CYP2A6 genetic polymorphisms and correlation with smoking status in Brazilians. Pharmacogenomics J. 2005;5(1):42-8.ABSTRACT; NO PDF

  1. GSTP1

Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, Matos HJ, Albano RM, Pinto LF. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis. 2007 Dec;28(12):2537-42.

  1. GSTP1

Burim RV, Canalle R, Martinelli Ade L, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004 Jul;19(4):291-8.

Burim RV, Canalle R, Martinelli Ade L, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004 Jul;19(4):291-8.

  1. GSTT1

Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, Matos HJ, Albano RM, Pinto LF. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis. 2007 Dec;28(12):2537-42.

Abnet CC, Fagundes RB, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan;28(1):112-7.

Gaspar PA, Hutz MH, Salzano FM, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Weimer TA. Polymorphisms of CYP1A1, CYP2A1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am J Phys Anthropol. 2002 Nov;119(3):249-56.

Burim RV, Canalle R, Martinelli Ade L, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004 Jul;19(4):291-8.

  1. GSTM1

Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, Matos HJ, Albano RM, Pinto LF. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis. 2007 Dec;28(12):2537-42.

Abnet CC, Fagundes RB, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan;28(1):112-7.

Gaspar PA, Hutz MH, Salzano FM, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Weimer TA. Polymorphisms of CYP1A1, CYP2A1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am J Phys Anthropol. 2002 Nov;119(3):249-56.

Burim RV, Canalle R, Martinelli Ade L, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004 Jul;19(4):291-8.

Marques CF, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A. Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol. 2006 Jul;42(6):632-7.

  1. NAT2

Marques CF, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A. Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol. 2006 Jul;42(6):632-7.

  1. CYP1A2

Abnet CC, Fagundes RB, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan;28(1):112-7.

  1. UGT

Abnet CC, Fagundes RB, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan;28(1):112-7.

  1. CYP2A1

Gaspar PA, Hutz MH, Salzano FM, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Weimer TA. Polymorphisms of CYP1A1, CYP2A1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am J Phys Anthropol. 2002 Nov;119(3):249-56.

  1. TP53

Gaspar PA, Hutz MH, Salzano FM, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Weimer TA. Polymorphisms of CYP1A1, CYP2A1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am J Phys Anthropol. 2002 Nov;119(3):249-56.

  1. CYP2E1

Gaspar PA, Hutz MH, Salzano FM, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Weimer TA. Polymorphisms of CYP1A1, CYP2A1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am J Phys Anthropol. 2002 Nov;119(3):249-56.

Gattás GJ, Soares-Vieira JA. Cytochrome P450-2E1 and glutathione S-transferase mu polymorphisms among Caucasians and mulattoes from Brazil. Occup Med (Lond). 2000 Sep;50(7):508-11.ABSTRACT; NO PDF

Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, Matos HJ, Albano RM, Pinto LF. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis. 2007 Dec;28(12):2537-42.

Rossini A, Lima SS, Rapozo DC, Faria M, Albano RM, Pinto LF. CYP2A6 and CYP2E1 polymorphisms in a Brazilian population living in Rio de Janeiro. Braz J Med Biol Res. 2006 Feb;39(2):195-201.

Burim RV, Canalle R, Martinelli Ade L, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004 Jul;19(4):291-8.

Marques CF, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A. Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol. 2006 Jul;42(6):632-7.

Sugimura H, Hamada GS, Suzuki I, Iwase T, Kiyokawa E, Kino I, Tsugane S. CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil. Pharmacogenetics. 1995;5 Spec No:S145-8.ABSTRACT; NO PDF

  1. CYP1A1

Abnet CC, Fagundes RB, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GSTM1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. Carcinogenesis. 2007 Jan;28(1):112-7.

Amorim LM, Lotsch PF, Simão Td Tde A, Gallo CV, Pinto LF. Analysis of CYP1A1 exon 7 polymorphisms by PCR-SSCP in a Brazilian population and description of two novel gene variations. Mutat Res. 2004 Mar 22;547(1-2):35-40.

Burim RV, Canalle R, Martinelli Ade L, Takahashi CS. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis. 2004 Jul;19(4):291-8.

Gaspar PA, Hutz MH, Salzano FM, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Weimer TA. Polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, and TP53 genes in Amerindians. Am J Phys Anthropol. 2002 Nov;119(3):249-56.

Maciel ME, Oliveira FK, Propst GB, da Graça Bicalho M, Cavalli IJ, Ribeiro EM. Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants. Genet Mol Biol. 2009 Oct;32(4):723-8.

Marques CF, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A. Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncol. 2006 Jul;42(6):632-7.

Sugimura H, Hamada GS, Suzuki I, Iwase T, Kiyokawa E, Kino I, Tsugane S. CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil. Pharmacogenetics. 1995;5 Spec No:S145-8.ABSTRACT; NO PDF

  1. CYP3A5

Suarez-Kurtz GPerini JABastos-Rodrigues LPena SDStruchiner C. 2007. Impact of population admixture on the distribution of the CYP3A5*3 polymorphism. Pharmacogenomics.  Oct;8(10):1299-306.

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